RT Journal
A1 DiNicolantonio JJ, O’Keefe JH, Lavie CJ
T1 BEnefits and risks of aspirin use
JF JAMA
JO JAMA
YR 2012
FD September 19
VO 308
IS 11
SP 1088
OP 1089
DO 10.1001/2012.jama.10717
UL http://dx.doi.org/10.1001/2012.jama.10717
AB 
To the Editor: Ms De Berardis and colleagues1 stated, “The benefit of aspirin for the primary prevention of cardiovascular events is relatively small for individuals with and without diabetes. This benefit could easily be offset by the risk of hemorrhage.” We disagree with their conclusion that aspirin use is associated with harm (major gastrointestinal or cerebral bleeding episodes) because they conducted a population-based cohort study, not a randomized controlled trial (RCT), and thus cannot prove causation.1