RT Journal
A1 Ludwig DS, Ebbeling CB, Feldman HA
T1 DIetary composition during weight-loss maintenance—reply
JF JAMA
JO JAMA
YR 2012
FD September 19
VO 308
IS 11
SP 1087
OP 1087
DO 10.1001/2012.jama.11620
UL http://dx.doi.org/10.1001/2012.jama.11620
AB 
In Reply:  Dr Weaver correctly observes that the trend test with equal spacing among diets from lowest to highest glycemic load (low-fat, low–glycemic index, and very low-carbohydrate diet) amounts to a pairwise comparison of the low-fat and very low-carbohydrate diets. We obtained an identical result, which was not reported, when the diets were spaced according to calculated glycemic load (185.1, 51.1, and 3.9 g/2000 kcal/d, respectively; P = .05). In any event, we subjected all outcomes to a 3-group analysis of variance and to a test for linear trend. We agree that the former is more stringent than the latter, and that interpretation of the CRP result requires caution. Some1- 2 but not all3 studies of this topic have similarly reported higher CRP levels for a low-carbohydrate vs low-fat diet, and this issue warrants additional study.