RT Journal T1 THe causes of some rapid changes in body weight JF JAMA JO JAMA YR 2012 FD September 19 VO 308 IS 11 SP 1074 OP 1074 DO 10.1001/jama.2012.3210 UL http://dx.doi.org/10.1001/jama.2012.3210 AB It is, of course, not unbelievable that material losses of stored tissue material may explain decided changes in body weight under certain conditions, As a matter of fact it has been difficult to make any sweeping statements as to the causes involved—as to whether such losses primarily involve water or metabolized tissue—because of the paucity of data on the water balance of the body. Few experimental researches furnish the data which will enable one to deduce the daily intake of water aside from that entering the body in the form of fluids; yet in view of the fact that most of our common food materials, such as meats, fruits, vegetables, etc., contain a large abundance of water, amounting usually to more than half and sometimes as high as 90 per cent. of the products ingested, obviously water enters the organism in varied association with the true nutrients. This content of water needs to be known before one can learn the whole story of the income und outgo. In addition to all this, water is formed by the oxidative reaction of metabolism; but this particular contribution is not readily ascertainable.