RT Journal A1 Whooley MA T1 DEpression treatment for patients with complex conditions—reply JF JAMA JO JAMA YR 2012 FD September 5 VO 308 IS 9 SP 860 OP 861 DO 10.1001/jama.2012.9738 UL http://dx.doi.org/10.1001/jama.2012.9738 AB Second, patients with depression have a high prevalence of comorbid anxiety disorders, and screening with the 2-item Generalized Anxiety Disorder scale can improve case identification. Whether routine screening for anxiety disorders benefits primary care patients has not been determined. However, first-line therapies (cognitive behavioral therapy and selective serotonin reuptake inhibitors) are the same for both depression and anxiety disorders,1- 3 so patients treated for major depressive disorder will usually receive therapy for both conditions.