RT Journal A1 Hampton T T1 PAthways to bone metastasis JF JAMA JO JAMA YR 2012 FD September 5 VO 308 IS 9 SP 853 OP 853 DO 10.1001/2012.jama.10870 UL http://dx.doi.org/10.1001/2012.jama.10870 AB By comparing primary and metastatic tumor cells in a mouse model of spontaneous bone metastasis, a team of investigators from Australia, Belgium, England, and the United States found that many genes that are suppressed in bone metastases are targets of the interferon regulatory factor Irf7, which promotes a robust immune response.