RT Journal A1 Jay JS, Gostin LO T1 EThical challenges of preexposure prophylaxis for hiv JF JAMA JO JAMA YR 2012 FD September 5 VO 308 IS 9 SP 867 OP 868 DO 10.1001/2012.jama.10158 UL http://dx.doi.org/10.1001/2012.jama.10158 AB On July 16, 2012, emtricitabine/tenofovir (Truvada; Gilead Sciences) became the first drug approved by the US Food and Drug Administration (FDA) for preexposure prophylaxis (PrEP) of human immunodeficiency virus (HIV) for adults at high risk. Clinical trials have demonstrated that daily use of oral antiretroviral drugs can reduce the risk of HIV acquisition through sexual intercourse. With 50 000 new HIV infections per year in the United States1 and 2 million per year worldwide,2 PrEP could become a major component of “combination prevention” along with condoms, counseling, testing, and treatment.