RT Journal T1 Notes from the field: Severe hand, foot, and mouth disease associated with coxsackievirus a6—alabama, connecticut, california, and nevada, november 2011–february 2012 JF JAMA JO JAMA YR 2012 FD July 25 VO 308 IS 4 SP 335 OP 335 DO UL http://dx.doi.org/ AB Hand, foot, and mouth disease (HFMD) is a common viral illness caused by enteroviruses that predominantly affects children aged <5 years. In the United States, outbreaks of HFMD typically occur during summer and autumn months. The most common cause of HFMD in the United States has been enterovirus serotype coxsackievirus A16. Most infections are asymptomatic; persons with signs and symptoms typically have a mild febrile illness with rash on the palms of the hands and soles of the feet, and sores in the mouth. HFMD also has been associated, often weeks after initial symptom onset, with nail dystrophies (e.g., Beau's lines or nail shedding).