RT Journal A1 Mateen FJ, Mills EJ T1 AGing and hiv-related cognitive loss JF JAMA JO JAMA YR 2012 FD July 25 VO 308 IS 4 SP 349 OP 350 DO 10.1001/jama.2012.8538 UL http://dx.doi.org/10.1001/jama.2012.8538 AB Although antiretroviral therapy has had a major effect on improving the survival of individuals with human immunodeficiency virus (HIV), cognitive disorders related to HIV remain an important burden of disease and disability worldwide. Among the more than 30 million adults living with HIV worldwide, a substantial proportion is estimated to have some form of HIV-associated neurocognitive disorders encompassing HIV dementia, mild neurocognitive impairment, and asymptomatic neurocognitive impairment.1 Conservative estimates from better resourced countries suggest that the number of individuals of all ages living with HIV-related cognitive disorders will increase 5- to 10- fold by 2030.2 Although data from Africa are sparse, 30% of the HIV-infected population in 1 Ugandan outpatient clinic experienced some form of HIV-associated cognitive loss.3