RT Journal A1 Hampton T T1 “Elite controllers” provide clues to keeping hiv infection in check JF JAMA JO JAMA YR 2012 FD July 25 VO 308 IS 4 SP 328 OP 329 DO 10.1001/jama.2012.8463 UL http://dx.doi.org/10.1001/jama.2012.8463 AB But for a minority of persons—about 1 in 300—antiretroviral medications aren't necessary. Some of these individuals have been infected with HIV for more than 30 years without developing progressive disease, and they have maintained low to undetectable levels of the virus in their blood without ever having taken antiretroviral drugs. While an untreated patient with HIV may have a viral load of more than a million HIV particles per milliliter of blood at the time of acute infection, elite controllers maintain an HIV viral load below 50 virus particles per milliliter of blood. Another group of untreated persons called viremic controllers maintain a viral load level ranging between 50 and 2000 particles.