RT Journal
A1 Carron P, Taffe P, Hugli O
T1 USe of epinephrine for cardiac arrest prior to hospital arrival
JF JAMA
JO JAMA
YR 2012
FD July 4
VO 308
IS 1
SP 29
OP 31
DO 10.1001/jama.2012.5942
UL http://dx.doi.org/10.1001/jama.2012.5942
AB 
First, their data show that the single most significant predictor of 1-month survival and good cerebral performance was the occurrence of ROSC (eTable 2 in article). The interval between the beginning of ventricular fibrillation and the occurrence of ROSC is a key predictor of these outcomes2; this time interval is not included in their analysis. Therefore, the use of epinephrine could be a surrogate marker of a more prolonged resuscitation and delayed ROSC in patients failing to respond to the initial defibrillation,3 and the time to ROSC a confounding factor for the effect of epinephrine. The time to ROSC is 1 of the core time events to be recorded in the Utstein template,4 allowing new analyses to be redone with the time from telephone call to ROSC as an additional factor.