RT Journal
A1 Humphries KH, Izadnegahdar M, Mackay MH
T1 SEx differences in presentation of myocardial infarction
JF JAMA
JO JAMA
YR 2012
FD June 20
VO 307
IS 23
SP 2486
OP 2487
DO 10.1001/jama.2012.5285
UL http://dx.doi.org/10.1001/jama.2012.5285
AB 
Canto et al1 identified a significant interaction between age and sex for chest pain at presentation. In other words, age is an important modifier of sex differences in chest pain presentation and therefore the results cannot be summarized without taking age into account.3 While the odds ratio for chest pain in men was greatest in the youngest age group, this does not imply that the youngest women are the least likely to present with chest pain. Chest pain was actually more common in the youngest women (81.5%) than in women in any other age group. Importantly, differences were more pronounced across age groups than between the sexes. The difference between women younger than 45 years compared with those aged 75 years or older was 31.9%. In contrast, the largest between-sex difference was only 7.1% in those aged 55 to 64 years.