RT Journal A1 Garbutt J, Spitznagel E, Piccirillo J T1 ACute rhinosinusitis treatment—reply JF JAMA JO JAMA YR 2012 FD June 13 VO 307 IS 22 SP 2368 OP 2370 DO 10.1001/jama.2012.4393 UL http://dx.doi.org/10.1001/jama.2012.4393 AB Because our goal was to determine if the clinical guidelines1 for the management of acute rhinosinusitis effectively identified those who would benefit from antibiotic treatment, we used those diagnostic criteria. We think it is unlikely that most patients simply had a cold because the median symptom duration was 10 days (mean, 11.2 days) and all participants described their symptoms as moderate or severe, not improving, or worsening.