RT Journal A1 Fourtounas C T1 VItamin d therapy and cardiac function in chronic kidney disease JF JAMA JO JAMA YR 2012 FD June 6 VO 307 IS 21 SP 2253 OP 2253 DO 10.1001/jama.2012.4168 UL http://dx.doi.org/10.1001/jama.2012.4168 AB To the Editor: The Paricalcitol Capsule Benefits in Renal Failure-Induced Cardiac Morbidity (PRIMO) trial by Dr Thadhani and colleagues1 failed to show any improvement in left ventricular mass index (LVMI) in patients with chronic kidney disease (CKD) after daily oral administration of paricalcitol for 48 weeks. Similar outcomes have been reported in other prospective studies of patients with CKD receiving erythropoiesis-stimulating agents.2- 3