RT Journal
A1 Hampton T
T1 COx-2 inhibitors and heart risks
JF JAMA
JO JAMA
YR 2012
FD June 6
VO 307
IS 21
SP 2247
OP 2247
DO 10.1001/jama.2012.5731
UL http://dx.doi.org/10.1001/jama.2012.5731
AB 
A team led by researchers in Pennsylvania confirmed that COX-2 is expressed in cells lining blood vessels and revealed that selectively removing it from the mouse vasculature reduced urinary excretion of the major metabolite of prostacyclin. This predisposed mice to thrombosis and hypertension. Urinary excretion of the metabolite varied inversely with blood pressure across all mutant mice.