RT Journal A1 Schlecht HP T1 PRevention of oral human papillomavirus infection—reply JF JAMA JO JAMA YR 2012 FD May 23 VO 307 IS 20 SP 2147 OP 2148 DO 10.1001/jama.2012.3653 UL http://dx.doi.org/10.1001/jama.2012.3653 AB In Reply: Dr Handsfield correctly points out that no data exist demonstrating that barrier protection prevents oral HPV infection during oral sex. Nevertheless, the Centers for Disease Control and Prevention encourages the use of barrier protection against sexually transmitted infections during oral sex and “with every sex act, from start to finish” in the hopes that this may prevent HPV transmission.1