RT Journal
T1 ÉTude toxicologique, physiologique et histophysiologique de l'hémoglobine en solution administrée à dose thérapeutique par vole veineuse à des chiens en état d'anémie aiguë par saignée
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD December 9
VO 113
IS 24
SP 2176
OP 2176
DO 10.1001/jama.1939.02800490072032
UL http://dx.doi.org/10.1001/jama.1939.02800490072032
AB This book, in organization and content, resembles a doctor's thesis as the term is understood in the United States. It consists almost entirely of experimental data obtained from a series of fifty-three dogs which were first exsanguinated and then given transfusions with solutions of canine or equine hemoglobin. The object of the study was to ascertain whether solutions of either homologous or heterologous hemoglobin could be used in the treatment of anemia from acute hemorrhage. Extensive data on the freezing-point depression, surface tension, specific gravity, viscosity, osmotic pressure, hydrogen ion concentration and electrolyte content of hemoglobin solutions are given. It was found that such solutions were toxic to many animals, producing mild azotemia with recovery or oliguria and uremia with fatal outcome. An acute syndrome sometimes occurred characterized by collapse, vomiting, diarrhea, hemorrhages from the entire gastrointestinal tract, and death within a few hours. In his toxicologic studies the author,