RT Journal
T1 CUrrent comment
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD December 9
VO 113
IS 24
SP 2154
OP 2154
DO 10.1001/jama.1939.02800490049015
UL http://dx.doi.org/10.1001/jama.1939.02800490049015
AB HISTAMINE IN PLATELETS OF RABBITS 
    From experiments originally intended to demonstrate the changes in blood histamine following vaccine administration, Zon, Ceder and Crigler1 obtained evidence suggesting that it is the platelets which carry major portions of the blood histamine. The rabbits in the experiment were sensitized to a strain of beta-hemolytic streptococcus of low virulence. Following the intravenous administration of 10 cc. of the killed homologous vaccine to sensitized animals and also to nonsensitized controls, blood samples were withdrawn and platelets, white cells and histamine were determined. There was an almost complete disappearance of granulocytic cells following the vaccine with little change in the total histamine content. Further, there was no increase in plasma histamine, which ruled out any shift in histamine from injured white cells to plasma. It was also shown that the administration of antiplatelet serum caused a significant drop in blood histamine generally paralleling the