RT Journal
A1 Friedrich MJ
T1 ARtemisinin-resistant malaria
JF JAMA
JO JAMA
YR 2012
FD May 16
VO 307
IS 19
SP 2017
OP 2017
DO 10.1001/jama.2012.5079
UL http://dx.doi.org/10.1001/jama.2012.5079
AB 
Rising failure rates with artemisinin-combination treatments (ACTs) have been noted in malaria clinics along the northwestern border of Thailand. In a study involving 3202 patients from these clinics who had been given oral ACTs over a 10-year period (2001-2010), the researchers found increases in the time taken to clear P falciparum parasites from the bloodstream, known as the parasite clearance half-life. The proportion of slow-clearing infections—with a half-life equal to or more than 6.2 hours—also increased during this decade, from 0.6% to 20%. Genetic analysis showed that this decline in clearance rates resulted from genetic factors that conferred artemisinin resistance.