RT Journal
A1 O’Donnell MJ, Schmieder RE, Yusuf S
T1 URinary sodium excretion and cardiovascular events—reply
JF JAMA
JO JAMA
YR 2012
FD March 21
VO 307
IS 11
SP 1138
OP 1139
DO 10.1001/jama.2012.327
UL http://dx.doi.org/10.1001/jama.2012.327
AB 
In Reply: We disagree with Dr Mann that findings from our study run “counter to the consistent evidence that, in individuals with hypertension, decreased sodium intake reduces blood pressure.” We did report a linear association between increased sodium excretion and increased blood pressure, consistent with several other studies.1 Our study is the largest one examining the relationship between measures of urinary sodium excretion (a proxy for intake) in patients at high cardiovascular risk and, consistent with several previous studies, we found an increased risk of cardiovascular events in those with high sodium excretion (>7 g/d), which supports the potential benefit of salt reduction in those with high salt intakes. However, a sodium excretion of less than 3 g/d also was associated with an increased risk of cardiovascular events.