RT Journal
A1 Canto JG, Kiefe CI, Greenland P
T1 COronary heart disease risk factors and mortality—reply
JF JAMA
JO JAMA
YR 2012
FD March 21
VO 307
IS 11
SP 1137
OP 1138
DO 10.1001/jama.2012.325
UL http://dx.doi.org/10.1001/jama.2012.325
AB 
Dr Santulli seeks additional information that may enhance our study, such as the influence of a dose-dependent effect of CHD risk factors, presence of the metabolic syndrome, other novel risk markers, and infarct size. Unfortunately, these factors were not available in the National Registry of Myocardial Infarction. Although baseline infarct size was not recorded, the finding of an inverse relationship between the number of CHD risk factors and mortality was consistently observed among patients with low-, intermediate-, and high-risk features using 2 well-validated measures of infarct severity (Killip classification and TIMI Risk Index).