RT Journal A1 Rosenberg L T1 ANtihypertensive agents and the risk of cancer—reply JF JAMA JO JAMA YR 1998 FD August 19 VO 280 IS 7 SP 600 OP 600 DO 10-1001/pubs.JAMA-ISSN-0098-7484-280-7-jbk0819 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-280-7-jbk0819 AB In Reply.—The suggestion of Drs Messerli and Grossman that concomitant diuretic use may account for the association of renal cell cancer with the use of calcium channel blockers, angiotensin-converting enzyme inhibitors, and β-blockers is plausible. However, it has been difficult to assess the separate effects of diuretics and antihypertensive drugs because they are so often used together.