RT Journal A1 Hampton T T1 EFfects of ect JF JAMA JO JAMA YR 2012 FD May 2 VO 307 IS 17 SP 1790 OP 1790 DO 10.1001/jama.2012.3723 UL http://dx.doi.org/10.1001/jama.2012.3723 AB Although clinicians have successfully used electroconvulsive therapy (ECT) to treat patients' severe depression for more than 70 years, the mechanisms by which it works remain unclear. Recent research from England suggests that use of electroconvulsive therapy (ECT) to treat patients' severe depression has lasting effects on the functional architecture of a specific region of the brain (Perrin JP et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1117206109 [published online March 19, 2012]).