RT Journal A1 Kim J, Davis JW T1 REcommendations on use of prostate-specific antigen for prostate cancer screening—reply JF JAMA JO JAMA YR 2012 FD April 4 VO 307 IS 13 SP 1372 OP 1374 DO 10.1001/jama.2012.398 UL http://dx.doi.org/10.1001/jama.2012.398 AB We also do not concur that our Commentary implied that being tested prevents metastatic disease and avoids prostate cancer–related death. What we described is what is observed when PSA screening is widely adopted: cases are detected earlier, causing a shift to detection of disease at earlier stages. This is a consequence of a change in the lens through which prostate cancer is observed.