RT Journal A1 Bagdasarian N T1 Open wound: The tragic obsession of dr. william beaumont JF JAMA JO JAMA YR 2012 FD April 18 VO 307 IS 15 SP 1648 OP 1649 DO 10.1001/jama.2012.495 UL http://dx.doi.org/10.1001/jama.2012.495 AB Open Wound: The Tragic Obsession of Dr William Beaumont by Jason Karlawish is a novel based on the life of a real-life 19th-century army surgeon best remembered for his study of human digestion. The surgeon, William Beaumont, published a text entitled Experiments and Observations on the Gastric Juice and the Physiology of Digestion in 1833, in which he described the chemical nature of digestion. Until that time, digestion had been considered by many to be a purely mechanical process in which food was churned and pulverized in the stomach. Beaumont's book received mixed reviews, but his story is intriguing for the methods he used to study human digestion.