RT Journal A1 Kuehn BM T1 HIv, hepatitis drug interactions JF JAMA JO JAMA YR 2012 FD March 28 VO 307 IS 12 SP 1243 OP 1243 DO 10.1001/jama.2012.332 UL http://dx.doi.org/10.1001/jama.2012.332 AB Citing evidence from a pharmacokinetic study, the FDA warned that patients taking the hepatitis C–targeted protease inhibitor boceprevir along with any of the ritonavir-boosted HIV-targeting protease inhibitors atazanavir, darunavir, or lopinavir may have lower blood levels of 1 or both drugs. The label of boceprevir will be updated to indicate this potential interaction, and the drug's manufacturer has sent letters to warn physicians.