RT Journal
A1 Friedrich MJ
T1 PRomising leishmaniasis drug
JF JAMA
JO JAMA
YR 2012
FD March 21
VO 307
IS 11
SP 1129
OP 1129
DO 10.1001/jama.2012.295
UL http://dx.doi.org/10.1001/jama.2012.295
AB 
Fexinidazole has been found safe in early clinical trials for African sleeping sickness, a disease caused by the parasite Trypanosoma brucei. Because visceral leishmaniasis is caused by a closely related protozoan parasite, Leishmania donovani, and current treatments for visceral leishmaniasis are less than ideal, scientists tested fexinidazole against leishmaniasis. They gave a daily oral dose of the compound for 5 days to leishmaniasis-infected mice and observed almost complete suppression of infection.