RT Journal A1 Armstrong K T1 CAn genomics bend the cost curve? JF JAMA JO JAMA YR 2012 FD March 14 VO 307 IS 10 SP 1031 OP 1032 DO 10.1001/jama.2012.261 UL http://dx.doi.org/10.1001/jama.2012.261 AB Prior approaches to slowing the growth in US health care costs have had limited success. The use of cost-benefit analyses to make coverage or clinical decisions has proven socially and politically unacceptable in the United States. Managed care temporarily slowed cost increases in health care but the public backlash against restriction of choice undermined its potential long-term effects. Similarly, the unwillingness to include economic outcomes in the current investment in comparative effectiveness research will limit its effects on health care costs.1 New approaches are needed.