RT Journal
A1 Hampton T
T1 PArkinson disease protein
JF JAMA
JO JAMA
YR 2012
FD March 7
VO 307
IS 9
SP 904
OP 904
DO 10.1001/jama.2012.224
UL http://dx.doi.org/10.1001/jama.2012.224
AB 
The researchers learned that when dopamine levels drop significantly, as they do in patients with Parkinson disease, RGS4 becomes overactive and disrupts brain circuits involved with learning. In mice that lacked RGS4, a drop in dopamine did not affect motor skills, while mice with normal levels of RGS4 experienced a significant loss of balance and coordination.