RT Journal
A1 Punnoose AR, Lynm C, Golub RM
T1 HEnoch-schönlein purpura
JF JAMA
JO JAMA
YR 2012
FD February 15
VO 307
IS 7
SP 742
OP 742
DO 10.1001/jama.2012.81
UL http://dx.doi.org/10.1001/jama.2012.81
AB 
Henoch-Schönlein purpura  (HSP) is a vasculitis  (inflammation of blood vessels) that affects small blood vessels mainly in the skin, intestines, and kidneys. Symptoms can begin in children, most commonly between the ages of 4 and 7 years, soon after an upper respiratory tract infection or a streptococcal pharyngitis  (sore throat infection). Children may develop arthritis  (inflammation of the joints), leading to pain. A rash may start as hive-like spots (urticaria ) or small raised red spots (erythematous maculopapules ) on the legs and buttocks. Eventually these spots blend to form bigger areas of bruising (purpura ) in the skin. Children may also develop abdominal pain that can be quite severe. Children younger than 2 years with HSP are more likely to develop edema  (swelling of various areas of their bodies), which is a result of leaky small blood vessels in the skin. Kidney involvement can also cause edema, hematuria  (visible or microscopic blood in the urine), or proteinuria (protein in the urine).