RT Journal
A1 Hampton T
T1 CReating cardiac muscle cells
JF JAMA
JO JAMA
YR 2012
FD February 1
VO 307
IS 5
SP 446
OP 446
DO 10.1001/jama.2012.70
UL http://dx.doi.org/10.1001/jama.2012.70
AB 
After screening nearly 4000 small molecules, the researchers discovered 3 structurally related molecules that could selectively enlarge the size of the developing zebrafish embryonic heart by stimulating the production of new cardiac muscle cells from stem cells. The compounds, which appear to oppose a signaling pathway known for its role in embryonic and heart development in embryos and embryonic stem cells, also stimulated mouse embryonic stem cells to differentiate into beating cardiac muscle cells.