RT Journal
A1 Abernethy AP, Currow DC
T1 TIme-limited trials
JF JAMA
JO JAMA
YR 2012
FD January 4
VO 307
IS 1
SP 33
OP 34
DO 10.1001/jama.2011.1954
UL http://dx.doi.org/10.1001/jama.2011.1954
AB 
To the Editor: The Commentary on time-limited trials (TLTs) of treatment by Drs Quill and Holloway underscores the need for an explicit process to better manage “major interventions in circumstances in which the outcome is uncertain.”1 The basic tenets of the authors' proposal included measurement of end points; agreement on a time point for reevaluation of an individual's therapeutic response; and reconsideration of the intervention, with possible continuation, dose reduction, or cessation based on response.