RT Journal A1 Kuehn BM T1 SErotonin syndrome update JF JAMA JO JAMA YR 2011 FD December 28 VO 306 IS 24 SP 2661 OP 2661 DO 10.1001/jama.2011.1868 UL http://dx.doi.org/10.1001/jama.2011.1868 AB The FDA had warned in July that linezolid (an antibiotic) or methylene blue (a drug used to treat methemoglobinemia that is also used as a marker or dye in some diagnostic procedures) can interact with drugs affecting the serotonin system. Since then, the agency learned that SSRIs and SNRIs are the psychiatric drugs most likely to trigger serotonin syndrome. The agency said it is not yet clear whether other psychiatric medications with weaker effects on the serotonin system are as likely to trigger these adverse events when used with linezolid or methylene blue.