RT Journal
A1 Friedrich MJ
T1 GEnetic susceptibility to dengue
JF JAMA
JO JAMA
YR 2011
FD December 21
VO 306
IS 23
SP 2553
OP 2553
DO 10.1001/jama.2011.1809
UL http://dx.doi.org/10.1001/jama.2011.1809
AB 
Certain populations are more susceptible to severe dengue, which is characterized by increased vascular permeability, and can lead to life-threatening hypovolemic shock. To investigate the genetic underpinnings of this susceptibility, the investigators compared the genomes of 2008 children with severe dengue in Vietnam against 2018 population control cases. They identified DNA variations in 2 genes— MICB and PLCE1 —that increased a child's susceptibility to DSS and replicated their findings in a follow-up sample of 1737 cases and 2934 controls.