RT Journal
A1 Ward PA
T1 IMmunosuppression in sepsis
JF JAMA
JO JAMA
YR 2011
FD December 21
VO 306
IS 23
SP 2618
OP 2619
DO 10.1001/jama.2011.1831
UL http://dx.doi.org/10.1001/jama.2011.1831
AB 
Abundant evidence exists in both animals and humans with sepsis for the appearance of a “cytokine storm,” characterized by high plasma levels of proinflammatory cytokines and chemokines,1 clinical signs of fever, tachycardia, and tachypnea and followed rapidly by development of shock, multiorgan failure, and death.2 Additional evidence indicates that sepsis can be associated with a state of immunosuppression, broadly defined as lymphopenia and loss of immune function, though the timing, incidence, and nature of the immunosuppression remain poorly characterized, especially in humans.3