RT Journal
A1 Kuehn BM
T1 NEw model system offers clues to als
JF JAMA
JO JAMA
YR 2011
FD October 12
VO 306
IS 14
SP 1534
OP 1534
DO 10.1001/jama.2011.1439
UL http://dx.doi.org/10.1001/jama.2011.1439
AB 
ALS is a progressive and ultimately fatal disorder in which the motor neurons in a patient's central nervous system die off, causing paralysis and eventually respiratory failure. Most cases are sporadic, but about 20% are linked to mutations in the superoxide dismutase 1 (SOD1) gene. However, scientists have so far been unable to identify the precise mechanisms behind the motor neuron loss.