RT Journal
A1 Hampton T
T1 MOlecules block heart amyloid
JF JAMA
JO JAMA
YR 2011
FD October 5
VO 306
IS 13
SP 1431
OP 1431
DO 10.1001/jama.2011.1392
UL http://dx.doi.org/10.1001/jama.2011.1392
AB 
A team led by researchers at Stanford University Medical School in California developed a fluorescence-based screening and identified 33 small molecules that target transthyretin and could potentially be developed into drugs. Four of these were found to be potent stabilizers of transthyretin and prevented its unfolding and aggregation. In human cardiomyocytes engineered to accumulate transthyretin aggregates, these 4 molecules were able to protect cells and remained effective in the presence of blood proteins.