RT Journal
A1 Angiolillo DJ
T1 Applying platelet function testing in clinical practice: What are the unmet needs?
JF JAMA
JO JAMA
YR 2011
FD September 21
VO 306
IS 11
SP 1260
OP 1261
DO 10.1001/jama.2011.1349
UL http://dx.doi.org/10.1001/jama.2011.1349
AB 
Clopidogrel is the most widely prescribed platelet P2Y12 receptor inhibitor and is recommended, in addition to aspirin, for prevention of atherothrombotic recurrences in patients with acute coronary syndromes (ACS) and for those undergoing percutaneous coronary interventions (PCI). Despite the proven efficacy of clopidogrel for patients in these high-risk settings, studies of platelet function testing (PFT) have shown broad variability in interindividual response to this pivotal antiplatelet agent.1 Importantly, PFT has prognostic implications because patients with high residual platelet reactivity (HRPR) vs low residual platelet reactivity (LRPR) have increased risks of ischemic and bleeding complications, respectively.2- 3 These observations have led to investigations aimed at defining the best platelet function test and cutoff values to predict adverse outcomes as well as treatment strategies associated with optimized levels of platelet inhibitory effects; the ultimate goal is to minimize ischemic and bleeding complications.1- 3