RT Journal
A1 Hampton T
T1 TUmors and telomeres
JF JAMA
JO JAMA
YR 2011
FD August 3
VO 306
IS 5
SP 480
OP 480
DO 10.1001/jama.2011.1087
UL http://dx.doi.org/10.1001/jama.2011.1087
AB 
In many cancers, an increased level of the enzyme telomerase helps keep telomeres intact, which helps cancer cells divide without normal limits. Investigators at the Johns Hopkins Medical Institutions in Baltimore found that inactivating mutations in the genes ATRX and DAXX may destabilize chromosomes' protective tips, but they also initiate a mechanism called alternative lengthening of telomeres (ALT) that allows tumor cells to maintain telomere length independent of telomerase.