RT Journal
A1 Friedrich MJ
T1 LIpid remodeling and obesity
JF JAMA
JO JAMA
YR 2011
FD July 20
VO 306
IS 3
SP 257
OP 257
DO 10.1001/jama.2011.962
UL http://dx.doi.org/10.1001/jama.2011.962
AB 
In the study, an analysis of the lipid composition of adipose tissue in pairs of monozygotic twins in which one twin was lean and the other obese but still metabolically healthy showed that composition of membrane phospholipids differed between the lean and obese twins. The researchers hypothesized that in obese individuals, changes in membrane lipid composition may be an adaptation to adipose tissue expansion that occurs to preserve the physical properties and function of the membranes. However, this protection comes with the cost of increasing vulnerability to inflammation, which can lead to metabolic disorders such as high blood pressure and diabetes.