RT Journal
A1 Suffredini AF, Munford RS
T1 NOvel therapies for septic shock over the past 4 decades
JF JAMA
JO JAMA
YR 2011
FD July 13
VO 306
IS 2
SP 194
OP 199
DO 10.1001/jama.2011.909
UL http://dx.doi.org/10.1001/jama.2011.909
AB Infections that result in shock and organ failure are a major public health problem worldwide. Severe sepsis and septic shock affect patients of all ages and often complicate chronic diseases. They are the major causes of death in critical care units and contribute substantially to hospital inpatient costs. Translating the scientific advances of the last 4 decades into clinical practice has been challenging. Despite many attempts to develop new therapies, the basic elements of treatment have not changed since the 1960s. In this Grand Rounds, we summarize the results of the clinical trials conducted during the last 4 decades, discuss some lessons learned, and suggest possible directions for future investigation.