RT Journal
A1 Simon P, Weiss F, Zimmer K, et al
T1 SPontaneous and sporadic trypsinogen mutations in idiopathic pancreatitis
JF JAMA
JO JAMA
YR 2002
FD November 6
VO 288
IS 17
SP 2122
OP 2122
DO 10.1001/jama.288.17.2118
UL http://dx.doi.org/10.1001/jama.288.17.2118
AB 
To the Editor: Hereditary pancreatitis is an
uncommon variety of pancreatitis. It generally follows an autosomal dominant
inheritance and is associated with germline mutations in the cationic trypsinogen
(PRSS1) gene.1 Thus,
genetic testing is often recommended when 2 or more family members are diagnosed
with idiopathic pancreatitis. However, the prevalence of trypsinogen mutations
among patients with idiopathic pancreatitis and without a family history remains
unknown.