RT Journal A1 Hlatky MA, Boothroyd D T1 POstmenopausal hormone replacement, body mass index, and quality of life—reply JF JAMA JO JAMA YR 2002 FD May 1 VO 287 IS 17 SP 2210 OP 2211 DO 10.1001/jama.287.17.2209 UL http://dx.doi.org/10.1001/jama.287.17.2209 AB In Reply: In response to Drs Rodriquez and Calle, only 28% of the women enrolled in HERS had a BMI of 25 kg/m2 or less, and only 5% had a BMI of 20.9 kg/m2 or less. We examined the quality-of-life measures in 3 strata of BMI: 25 kg/m2 or less, more than 25 through 30 kg/m2, and more than 30 kg/m2. Overall quality of life scores declined significantly with increasing BMI. None of the tests for interaction between treatment assigned, follow-up time, and BMI were statistically significant, however, and there were no consistent trends between BMI and an effect of hormone therapy on quality of life.