RT Journal A1 Fontanarosa PB, Burkhart CG, Burkhart CN T1 ARe magnets effective for pain control? JF JAMA JO JAMA YR 2000 FD August 2 VO 284 IS 5 SP 564 OP 566 DO 10.1001/jama.284.5.561 UL http://dx.doi.org/10.1001/jama.284.5.561 AB To the Editor: Dr Collacott and colleagues1 found that magnets were ineffective in treating low back pain. Inasmuch as electromagnetic fields are known to alter biomolecular DNA synthesis, cell proliferation, membrane calcium fluxes, and cell surface properties in vitro,2 they may nonetheless be beneficial in treating patients with various disease states. The principal site of biophysical interaction leading to cell functional alterations with magnets is most likely the lipid membrane surface, where electromagnetic radiation may affect the ability of ion pump enzymes to move calcium, sodium, and potassium ions across the cell membranes.3