RT Journal A1 Mitka M T1 TRansmissible spongiform encephalopathies and the us blood supply—reply JF JAMA JO JAMA YR 1999 FD December 22 VO 282 IS 24 SP 2301 OP 2302 DO 10-1001/pubs.JAMA-ISSN-0098-7484-282-24-jbk1222 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-282-24-jbk1222 AB In Reply: I appreciate that Dr Wilkinson may disagree with my use of language; however, the offending phrases quoted in her letter are taken out of context and appear more sensational than they actually are. Her point that I wrote a factual inaccuracy is partially correct. Current FDA policy does defer blood donations by individuals with classic CJD. However, Wilkinson's statement that previous donations of blood and blood components from such individuals are discarded is not fully accurate. On September 8, 1998, the FDA issued a change to its guidance governing blood donations involving people with CJD.1 The guidance involved plasma derivatives and indicated that such blood products would be allowed even if they came from donors who subsequently develop classic CJD (new variant CJD blood products would still be subject to retrieval, quarantine, and destruction).