RT Journal A1 Gershon SK, Chang AC, Purvis WV, Salive M T1 HIstory of biology JF JAMA JO JAMA YR 1999 FD November 24 VO 282 IS 20 SP 1919 OP 1919 DO 10-1001/pubs.JAMA-ISSN-0098-7484-282-20-jbk1124 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-282-20-jbk1124 AB To the Editor: The Center for Biologics Evaluation and Research at the Food and Drug Administration (FDA) has received reports through MEDWATCH of 3 fatalities and 1 serious but nonfatal adverse event following the improper administration of topical thrombin (bovine origin) USP by several inappropriate methods.