RT Journal A1 Holmes WC, Slap GB T1 INterpretation of research on sexual abuse of boys—reply JF JAMA JO JAMA YR 1999 FD June 16 VO 281 IS 23 SP 2185 OP 2185 DO 10-1001/pubs.JAMA-ISSN-0098-7484-281-23-jac90005 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-23-jac90005 AB In Reply: We agree with the conjecture made by Dr Rind and colleagues that sequelae rates differ by sample type. Clinical samples probably demonstrate more adverse health states following sexual abuse than nonclinical samples. In fact, repeat perusal of the studies informing the sequelae section of our article indicates that base rates of outcomes do differ by sample type. However, the rate increases we reported (comparing abused with nonabused boys within sample type) do not. We avoided meta-analytic assessment of studies on male sexual abuse due to the wide variability in design rigor, abuse definitions, and data collection and analytic methods. Meta-analysis is not appropriate when methodological rigor, let alone the question asked, is so varied.