RT Journal A1 Henley E T1 COst-effectiveness of interferon treatment for hepatitis c JF JAMA JO JAMA YR 1999 FD June 9 VO 281 IS 22 SP 2083 OP 2084 DO 10.1001/jama.281.22.2083 UL http://dx.doi.org/10.1001/jama.281.22.2083 AB Like many readers, I understand the concept and importance of cost-effectiveness analysis but lack the knowledge, time, and energy to carefully analyze the strategies used by authors in performing the analysis. Of particular importance are the various assumptions that need to be made regarding outcomes at different stages. In the article by Wong et al, results of 3 retrospective studies were pooled to obtain the natural history of hepatitis C, and an expert panel of hepatologists was used to assess utilities for different health states.