RT Journal A1 Straus SE, McKenzie R, Demitrack MA T1 LOw-dose hydrocortisone for chronic fatigue syndrome—reply JF JAMA JO JAMA YR 1999 FD May 26 VO 281 IS 20 SP 1887 OP 1889 DO 10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526 AB Dr Baschetti and Dr Teitelbaum and colleagues suggest that the dosage we used was too high. We based our regimen on our prior observation that CFS patients secrete approximately 30% less cortisol per day than healthy subjects.2 Our hypothesis was that modest glucocorticoid supplementation might ameliorate CFS symptoms.