RT Journal
A1 Ahnen DJ, Byers T
T1 CAlcium intake and colon cancer biomarkers—reply
JF JAMA
JO JAMA
YR 1999
FD April 7
VO 281
IS 13
SP 1172
OP 1172
DO 10-1001/pubs.JAMA-ISSN-0098-7484-281-13-jbk0407
UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-13-jbk0407
AB 
In Reply: Dr Holt and colleagues
believe that our Editorial missed the major points that they had made
in interpreting the findings from their trial.1 We believe that we have not missed those points, rather that we have simply
disagreed with their interpretation. For the reasons we stated in our
Editorial, we concluded, and still believe, that the biomarkers used in
the study by Holt et al have unproven clinical utility. In the absence
of formal validation of any of the biomarkers used, the results provide
weak evidence for making dietary recommendations, the stated conclusion
of the original article,1 and are of 
limited value for the
planning of future research studies, now stated as the conclusion in
their letter.