RT Journal A1 Kempen P T1 MAnaging pain in elderly patients JF JAMA JO JAMA YR 1999 FD February 17 VO 281 IS 7 SP 605 OP 606 DO 10-1001/pubs.JAMA-ISSN-0098-7484-281-7-jbk0217 UL http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-7-jbk0217 AB Pain is not always constant or somatic, and while often readily mitigated, cannot always be eliminated or prevented for many physiological, pharmacodynamic, personal, and psychological reasons. All effective medications have adverse effects, many of which are significant and some potentially deadly. Indeed, patients with cancer have daily pain, as the goal is typically to weigh risk vs benefit of medications to afford the best quality of life possible, often limited to tolerable pain. Even general anesthesia does not eliminate pain, as clearly autonomic evidence of pain is routinely detectable during surgery. Only the experience of pain is effectively suppressed. For treatment of acute pain, suppression of consciousness is logical and useful, but cannot be the goal in chronic pain states, as conscious experience of events is central to quality of life. Increasing pain associated with progressive disease vs obtundation of consciousness is a stark reality for individuals at life's end.